2024 Spasticity Management 101 - Treatment Modalities-Spasticity Treatment Options: Oral Pharmacology

Video Transcription

Video Summary

In this presentation, Dr. Marilyn Pacheco discusses oral pharmacology as a treatment option for spasticity. Five widely used oral medications for spasticity are discussed: Benzodiazepine, Baclofen, Dantrolene sodium, Clonidine, and Tizanidine.<br /><br />Dr. Pacheco explains that the challenge in treating spasticity is finding a balance between improved function and patient satisfaction while minimizing side effects. High doses of oral medications can cause sedation and changes in mood and cognition.<br /><br />She explains that the most effective medications for spasticity are those that enhance neuronal inhibition. Benzodiazepines and Baclofen affect processes involving the inhibitory neurotransmitter GABA. Tizanidine and Clonidine exert effects on norepinephrine receptors. Dantrolene sodium primarily acts at the musculature level. Other medications, such as Cyproheptadine, Cannabinoids, and Orfenadrine, have varying levels of effectiveness.<br /><br />Dr. Pacheco provides information on the pharmacokinetics and dosages of each medication, as well as their common side effects. She also mentions the contraindications and precautions for each medication.<br /><br />Overall, this presentation aims to educate healthcare professionals on the use of oral medications for spasticity and help them make informed decisions when prescribing these medications to patients.

Keywords

oral pharmacology

spasticity treatment

Benzodiazepine

Baclofen

Tizanidine

neurotransmitter GABA

pharmacokinetics