Auto-Antibody Negative Necrotizing Myopathy with Rare Cardiac Involvement and Incorporating Evidence Based Treatment Guidelines-Auto-Antibody Negative Necrotizing Myopathy with Rare Cardiac Involvement and Incorporating Evidence Based Treatment Guidelines

Auto-Antibody Negative Necrotizing Myopathy with Rare Cardiac Involvement and Incorporating Evidence Based Treatment Guidelines

Back to course

Video Transcription

Video Summary

This video discusses the case of a 45-year-old male with autoantibody-negative necrotizing myopathy, a type of inflammatory myopathy. He presented with muscle weakness, weight loss, and elevated enzyme levels. The patient also showed cardiac involvement, with abnormalities observed in an echocardiogram and later confirmed through cardiac MRI and biopsy, indicating myocarditis. The treatment included high-dose corticosteroids, IVIG, and other medications. The patient showed improvement in muscle strength but unfortunately experienced a sudden unexplained death, presumed to be due to a cardiac arrhythmia. The video suggests further evaluation for cardiac involvement in necrotizing myopathy cases, including routine screening tools such as troponin levels, EKG, and echocardiogram, as well as appropriate malignancy screenings. Treatment involves corticosteroids and other disease-modifying agents.

Keywords

autoantibody-negative necrotizing myopathy

inflammatory myopathy

muscle weakness

cardiac involvement

myocarditis