Background and Pathophysiology of Migraine Headache-Understanding Migraine Pathophysiology and Triggers

Understanding Migraine Pathophysiology and Triggers

Video Transcription

Video Summary

This micro-lecture details migraine pathophysiology and triggers, emphasizing the importance of the calcitonin gene-related peptide (CGRP). Key objectives include recognizing headache triggers, understanding migraine phases, evaluating CGRP's role, and linking pathophysiology to treatment. Migraine involves complex mechanisms including central and peripheral triggers, neurogenic inflammation, and CGRP release, which is involved in both pain and inflammation. Elevated CGRP levels are noted during and between migraine attacks, and CGRP antagonists and antibodies show promise in migraine management. Understanding CGRP’s role is crucial for effective treatment strategies.

Keywords

migraine pathophysiology

CGRP

headache triggers

neurogenic inflammation

CGRP antagonists