Journal CME, December 2023: Efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair: A systematic review and meta-analysis-Journal CME, December 2023: Efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair: A systematic review and meta-analysis

Journal CME, December 2023: Efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair: A systematic review and meta-analysis

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A systematic review and meta-analysis was conducted to evaluate the efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in arthroscopic rotator cuff repair. Ten randomized controlled trials with a total of 628 patients were included in the analysis. The results showed that augmenting rotator cuff repair with PRP reduced the retear rates compared to surgery alone. However, PRF had no effect on retear rates. In terms of clinical function, PRP improved Constant-Murley scores and University of California, Los Angeles scores, while PRF only improved Constant-Murley scores. However, the improvements in clinical function were small and below the minimum clinically important difference threshold. The study concluded that PRP can reduce retear rates and improve clinical function scores compared to arthroscopic rotator cuff repair alone. However, the application of PRF did not provide any clinically meaningful benefit. The study highlighted the limitations of the current evidence, including the small number and heterogeneity of studies, methodological limitations, and risk of bias. Further high-quality studies are needed to validate these findings.

Keywords

systematic review

meta-analysis

PRP

PRF

rotator cuff repair

retear rates

clinical function

Constant-Murley scores

surgery

improvements