Pain and Spine Scientific Session-Session Presentation

Video Transcription

Video Summary

This presentation discusses the differential expression of microRNAs in patients with spinal cord injuries who use opioid medications. The researchers found that two microRNAs, microRNA 132B and microRNA 92B, were significantly differentially expressed in patients using opioids compared to non-users. Additionally, they found that microRNA 132B levels increased as pain severity levels increased, while microRNA 92B levels decreased. The study also found a significant relationship between microRNA 132B and smoking status. The researchers observed that microRNA regulation mechanisms might be more pronounced in patients after exposure to traumatic or neurotrauma. The study suggests that microRNAs may play a role in opioid tolerance and regulation, inhibiting several key processes within the nervous system for repair and recovery. The results of this study lay the foundation for additional research on microRNA expression and its relationship to opioid use in patients with spinal cord injuries. The researchers hope that further research in this area will help develop better treatment options for this medically complex patient population.

Keywords

differential expression

microRNAs

spinal cord injuries

opioid medications

microRNA 132B

microRNA 92B

pain severity levels

smoking status

microRNA regulation mechanisms

opioid tolerance