Proximal Muscle Weakness, Generalized Rash, and Idiopathic Pulmonary Fibrosis in an Adult Female with Anti-Synthetase Syndrome: A Case Report-Proximal Muscle Weakness, Generalized Rash, and Idiopathic Pulmonary Fibrosis in an Adult Female with Anti-Synthetase Syndrome: A Case Report

Proximal Muscle Weakness, Generalized Rash, and Idiopathic Pulmonary Fibrosis in an Adult Female with Anti-Synthetase Syndrome: A Case Report

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Video Summary

The case discussed is about a 67-year-old female with proximal muscle weakness, generalized rash, and idiopathic pulmonary fibrosis. She was diagnosed with antisynthetase syndrome, an autoimmune disease characterized by antibodies that target aminoacyl-tRNA synthetases. The patient presented with a rash, muscle weakness, and elevated lab markers. Various consultations and tests were done, including a skin biopsy and muscle biopsy. Treatment with steroids and rehabilitation therapy led to improvement. The patient was diagnosed with anti-PL12 antibody-positive antisynthetase syndrome and started on mycophenolate mofetil. The case highlights the importance of considering antisynthetase syndrome in patients with these symptoms and the impact it can have on prognosis.

Keywords

proximal muscle weakness

generalized rash

antisynthetase syndrome

autoimmune disease

mycophenolate mofetil