It is widely acknowledged that systematic study is needed to develop an evidence-based approach for caring for patients with Post-Acute Sequelae of SARS-CoV-2 infection (PASC). At present, there is a dearth of rigorous scientific evidence regarding effective assessment and treatment of PASC that prevents the creation of evidence-based clinical guidelines. However, the United States (U.S.) health system is currently seeing an increase in the number of patients presenting with PASC, and is in urgent need of clinical guidance in treating these patients. The goal of this, and future statements, is to provide practical guidance to clinicians in the assessment and treatment of patients presenting with PASC. This Consensus Guidance Statement on fatigue is the first of a series focused on the most prominent PASC symptoms.

Upon completion of this activity, participants will be able to:
• Recognize and Apply the PASC Consensus Guidance Statement Methods into everyday practice
• Identify and Diagnose Fatigue in Individuals with PASC
• Analyze PASC Fatigue Presentation and Assessment Recommendations
• Differentiate and Apply PASC Fatigue Treatment Recommendations
• Identify Health Equity Considerations and Examples in PASC Fatigue
• Summarize the Future Directions in Assessing and Treating PASC-Related Fatigue

These Consensus Guidance Statements are intended to reflect current best practices in patient assessment, testing, and treatments. They should not preclude clinical judgment and must be applied in the context of the specific patient, with adjustments for patient preferences, comorbidities, and other factors.

Faculty
• Janna L. Friedly, MD, PM&R Journal Editor in Chief
• Joseph E. Herrera, DO, Icahn School of Medicine at Mount Sinai
• William N. Niehaus, MD, University of Colorado School of Medicine
• Jonathan H. Whiteson, MD, Rusk Rehabilitation, NYU Langone Health
• John M. Baratta, MD, MBA, UNC-Chapel Hill
• Talya K. Fleming, MD, JFK Johnson Rehabilitation Institute at Hackensack Meridian Health
• Huma H. Naqvi, MD, Hartford HealthCare’s COVID Recovery Center
• Benjamin A. Abramoff, MD, MS, Penn Medicine
• Stuart M. Weinstein, MD, University of Washington
• Alba M. Azola, MD, Johns Hopkins University